Recombinant Human INPP5B cell lysate

• Cat.No.: INPP5B-861HCL

Specification

• Description: Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: INPP5B inositol polyphosphate-5-phosphatase, 75kDa [ Homo sapiens ]
• Official Symbol: INPP5B
• Synonyms: INPP5B; inositol polyphosphate-5-phosphatase, 75kDa; inositol polyphosphate 5 phosphatase, 75kD; type II inositol 1,4,5-trisphosphate 5-phosphatase; phosphoinositide 5-phosphatase; 75 kDa inositol polyphosphate-5-phosphatase; type II inositol-1,4,5-trisphosphate 5-phosphatase; 5PTase; MGC65156; MGC71303
• Gene ID: 3633
• mRNA Refseq: NM_005540
• Protein Refseq: NP_005531
• MIM: 147264
• UniProt ID: P32019
• Chromosome Location: 1p34
• Pathway: 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), organism-specific biosystem; 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), conserved biosystem; 3-phosphoinositide degradation, organism-specific biosystem; 3-phosphoinositide degradation, conserved biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, conserved biosystem; D-myo-inositol (1,4,5)-trisphosphate degradation, organism-specific biosystem
• Function: hydrolase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein binding