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Recombinant Human Interleukin 11
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Cat.No. : | IL11-218H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human interleukin 11 DNA sequence encoding the mature 173 ammino acid human IL-11 protein sequence was inserted into a suitable expression vector and was expressed inSf21 insect cellsusing a baculovirus expression system. |
Description : | Interleukin 11 (IL-11) is a multifunctional cytokine isolated from bone marrow-derived stromal cells. It is a key regulator of multiple events in hemtaopoiesis, most notably the stimulation of megakaryocyte maturation. It is also known under the names Adipogenesis inhibitory factor (AGIF) and Oprelvekin. IL-11 improves platelet recovery after chemotherapy-induced thrombocytopenia, induces acute phase proteins, modulates antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. Besides from lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many tissues such as brain, gut and testis. |
Source : | Sf21 Insect Cells. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-11 is Mr 19 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 23 kDa. |
State Of Matter : | Solution. |
Formulation : | This recombinant protein solution was 0.2 µm filtered and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present. The final protein concentration is 0.25 mg/ml. |
Purity : | > 97% by SDS Page and analyzed by silver stain. |
Endotoxin : | < 0.1 ng per 1 µg as determined by the LAL method. |
Biological Activity : | The biological activity of Human IL-11 was determined by a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11. The expected ED50 for this effect is typically 0.06 - 0.24 ng/mL. |
Storage And Stability : | Working aliquots of this recombinant protein solution are stable for up to twelve months at -20˚C to -70˚C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at 2˚C - 8˚C for one month without detectable loss of activity. For long-term storage, aliquot and freeze at -20˚C to -70˚C in a manual defrost freezer. Avoid repeated freeze thaw cycles. |
Gene Name : | IL11 interleukin 11 [ Homo sapiens ] |
Synonyms : | AGIF; IL-11; Adipogenesis inhibitory factor, Oprelvekin, Interleukin-11; IL11; interleukin 11 |
Gene ID : | 3589 |
mRNA Refseq : | NM_000641 |
Protein Refseq : | NP_000632 |
UniProt ID : | P20809 |
Chromosome Location : | 19q13.3-q13.4 |
MIM : | 147681 |
Pathway : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway |
Function : | cytokine activity, interleukin-11 receptor binding activity |
◆ Recombinant Protein
IL11-061H | Recombinant Human IL11 Protein | +Inquiry |
Il11-1659R | Recombinant Rat Il11 Protein, His-tagged | +Inquiry |
IL11-137H | Recombinant Active Human IL11 Protein, His-tagged(N-ter) | +Inquiry |
IL11-130H | Recombinant Human IL11 Protein | +Inquiry |
IL11-259I | Recombinant Human IL11 Protein | +Inquiry |
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◆ Lysates
IL11-5249HCL | Recombinant Human IL11 293 Cell Lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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