| Description : |
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
104.9 kDa |
| AA Sequence : |
MDAPKAGYAFEYLIETLNDSSHKKF FDVSKLGTKYDVLPYSIRVLLEAAV RNCDGFLMKKEDVMNILDWKTKQSN VEVPFFPARVLLQDFTGIPAMVDFA AMREAVKTLGGDPEKVHPACPTDLT VDHSLQIDFSKCAIQNAPNPGGGDL QKAGKLSPLKVQPKKLPCRGQTTCR GSCDSGELGRNSGTFSSQIENTPIL CPFHLQPVPEPETVLKNQEVEFGRN RERLQFFKWSSRVFKNVAVIPPGTG MAHQINLEYLSRVVFEEKDLLFPDS VVGTDSHITMVNGLGILGWGVGGIE TEAVMLGLPVSLTLPEVVGCELTGS SNPFVTSIDVVLGITKHLRQVGVAG KFVEFFGSGVSQLSIVDRTTIANMC PEYGAILSFFPVDNVTLKHLEHTGF SKAKLESMETYLKAVKLFRNDQNSS GEPEYSQVIQINLNSIVPSVSGPKR PQDRVAVTDMKSDFQACLNEKVGFK GFQIAAEKQKDIVSIHYEGSEYKLS HGSVVIAAVISCTNNCNPSVMLAAG LLAKKAVEAGLRVKPYIRTSLSPGS GMVTHYLSSSGVLPYLSKLGFEIVG YGCSTCVGNTAPLSDAVLNAVKQGD LVTCGILSGNKNFEGRLCDCVRANY LASPPLVVAYAIAGTVNIDFQTEPL GTDPTGKNIYLHDIWPSREEVHRVE EEHVILSMFKALKDKIEMGNKRWNS LEAPDSVLFPWDLKSTYIRCPSFFD KLTKEPIALQAIENAHVLLYLGDSV TTDHISPAGSIARNSAAAKYLTNRG LTPREFNSYGARRGNDAVMTRGTFA NIKLFNKFIGKPAPKTIHFPSGQTL DVFEAAELYQKEGIPLIILAGKKYG SGNSRDWAAKGPYLLGVKAVLAESY EKIHKDHLIGIGIAPLQFLPGENAD SLGLSGRETFSLTFPEELSPGITLN IQTSTGKVFSVIASFEDDVEITLYK HGGLLNFVARKFSTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
