Recombinant Human ITM2C Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ITM2C-2959H
• Product Overview: ITM2C MS Standard C13 and N15-labeled recombinant protein (NP_001012532) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
• Molecular Mass: 25 kDa
• AA Sequence: MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPARLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVVTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ITM2C integral membrane protein 2C [ Homo sapiens (human) ]
• Official Symbol: ITM2C
• Synonyms: ITM2C; integral membrane protein 2C; BRI3; E25; hRPC.1050_D_4; ITM3; E25C; HRPC.1050_D_4
• Gene ID: 81618
• mRNA Refseq: NM_001012514
• Protein Refseq: NP_001012532
• MIM: 609554
• UniProt ID: Q9NQX7