Recombinant Human KAT5 Protein (3-513 aa), His-tagged

• Cat.No.: KAT5-1302H
• Product Overview: Recombinant Human KAT5 Protein (3-513 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Immunology. Protein Description: Partial.

Specification

• Description: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the roval of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 62.4 kDa
• Protein length: 3-513 aa
• AA Sequence: EVGEIIEGCRLPVLRRNQDNEDEWP LAEILSVKDISGRKLFYVHYIDFNK RLDEWVTHERLDLKKIQFPKKEAKT PTKNGLPGSRPGSPEREVPASAQAS GKTLPIPVQITLRFNLPKEREAIPG GEPDQPLSSSSCLQPNHRSTKRKVE VVSPATPVPSETAPASVFPQNGAAR RAVAAQPGRKRKSNCLGTDEDSQDS SDGIPSAPRMTGSLVSDRSHDDIVT RMKNIECIELGRHRLKPWYFSPYPQ ELTTLPVLYLCEFCLKYGRSLKCLQ RHLTKCDLRHPPGNEIYRKGTISFF EIDGRKNKSYSQNLCLLAKCFLDHK TLYYDTDPFLFYVMTEYDCKGFHIV GYFSKEKESTEDYNVACILTLPPYQ RRGYGKLLIEFSYELSKVEGKTGTP EKPLSDLGLLSYRSYWSQTILEILM GLKSESGERPQITINEISEITSIKK EDVISTLQYLNLINYYKGQYILTLS EDIVDGHERAMLKRLLRIDSKCLHF TPKDWSKRGKW
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: KAT5 K(lysine) acetyltransferase 5 [ Homo sapiens ]
• Official Symbol: KAT5
• Synonyms: KAT5; cPLA2; ESA1; HTATIP1; PLIP; TIP60; TIP; HTATIP
• Gene ID: 10524
• mRNA Refseq: NM_001206833
• Protein Refseq: NP_001193762
• MIM: 601409
• UniProt ID: Q92993