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Recombinant Human KAZALD1 protein, His & T7-tagged

Cat.No. : KAZALD1-1872H
Product Overview : Recombinant Human KAZALD1 aa. (Arg31~Tyr304 (Accession # Q96I82)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a secreted member of the insulin growth factor-binding protein (IGFBP) superfamily. The protein contains an insulin growth factor-binding domain in its N-terminal region, a Kazal-type serine protease inhibitor and follistatin-like domain in its central region, and an immunoglobulin-like domain in its C-terminal region. Studies of the mouse ortholog suggest that this protein may function in bone development and bone regeneration. This gene is hypomethylated and over-expressed in high-grade glioma compared to low-grade glioma, and thus the hypomethylated gene may be associated with cell proliferation and the shorter survival of patients with high-grade glioma. It is also one of numerous genes found to be deleted in a novel 5.54 Mb interstitial deletion, which is associated with multiple congenital anomalies. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : 37kDa as determined by SDS-PAGE reducing conditions.
Protein length : Arg31~Tyr304 (Accession # Q96I82)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >90%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Isoelectric Point : 4.6
Gene Name : KAZALD1 Kazal type serine peptidase inhibitor domain 1 [ Homo sapiens (human) ]
Official Symbol : KAZALD1
Synonyms : KAZALD1; Kazal type serine peptidase inhibitor domain 1; BONO1; FKSG28; FKSG40; IGFBP-rP10; kazal-type serine protease inhibitor domain-containing protein 1; IGFBP-related protein 10; bone- and odontoblast-expressed gene 1; novel kazal-type serine protease inhibitor domain and immunoglobulin domain containing protein
Gene ID : 81621
mRNA Refseq : NM_001319303.1
Protein Refseq : NP_001306232.1
UniProt ID : Q96I82

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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