Recombinant Human KCNAB2 Protein (1-367 aa), His-SUMO-tagged

• Cat.No.: KCNAB2-593H
• Product Overview: Recombinant Human KCNAB2 Protein (1-367 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Neuroscience. Protein Description: Full Length.

Specification

• Description: Cytoplasmic domain potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits . Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability . Promotes expression of the pore-forming alpha subunits at the cell mbrane, and thereby increases channel activity . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore . Promotes KCNA4 channel closure . Modulates the functional properties of KCNA5 . Enhances KCNB2 channel activity . Binds NADPH and has NADPH-dependent aldoketoreductase activity . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro).
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 57.0 kDa
• Protein length: 1-367 aa
• AA Sequence: MYPESTTGSPARLSLRQTGSPGMIY STRYGSPKRQLQFYRNLGKSGLRVS CLGLGTWVTFGGQITDEMAEQLMTL AYDNGINLFDTAEVYAAGKAEVVLG NIIKKKGWRRSSLVITTKIFWGGKA ETERGLSRKHIIEGLKASLERLQLE YVDVVFANRPDPNTPMEETVRAMTH VINQGMAMYWGTSRWSSMEIMEAYS VARQFNLTPPICEQAEYHMFQREKV EVQLPELFHKIGVGAMTWSPLACGI VSGKYDSGIPPYSRASLKGYQWLKD KILSEEGRRQQAKLKELQAIAERLG CTLPQLAIAWCLRNEGVSSVLLGAS NADQLMENIGAIQVLPKLSSSIIHE IDSILGNKPYSKKDYRS
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 [ Homo sapiens ]
• Official Symbol: KCNAB2
• Synonyms: KCNAB2; AKR6A5; HKvbeta2.1; HKvbeta2.2; KCNA2B; HKvbeta2; KV-BETA-2; MGC117289
• Gene ID: 8514
• mRNA Refseq: NM_001199860
• Protein Refseq: NP_001186789
• MIM: 601142
• UniProt ID: Q13303