| Description : |
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
71 kDa |
| AA Sequence : |
MAEAPPRRLGLGPPPGDAPRAELVA LTAVQSEQGEAGGGGSPRRLGLLGS PLPPGAPLPGPGSGSGSACGQRSSA AHKRYRRLQNWVYNVLERPRGWAFV YHVFIFLLVFSCLVLSVLSTIQEHQ ELANECLLILEFVMIVVFGLEYIVR VWSAGCCCRYRGWQGRFRFARKPFC VIDFIVFVASVAVIAAGTQGNIFAT SALRSMRFLQILRMVRMDRRGGTWK LLGSVVYAHSKELITAWYIGFLVLI FASFLVYLAEKDANSDFSSYADSLW WGTITLTTIGYGDKTPHTWLGRVLA AGFALLGISFFALPAGILGSGFALK VQEQHRQKHFEKRRMPAANLIQAAW RLYSTDMSRAYLTATWYYYDSILPS FSSRMGIKDRIRMGSSQRRTGPSKQ HLAPPTMPTSPSSEQVGEATSPTKV QKSWSFNDRTRFRASLRLKPRTSAE DAPSEEVAEEKSYQCELTVDDIMPA VKTVIRSIRILKFLVAKRKFKETLR PYDVKDVIEQYSAGHLDMLGRIKSL QTRVDQIVGRGPGDRKAREKGDKGP SDAEVVDEISMMGRVVKVEKQVQSI EHKLDLLLGFYSRCLRSGTSASLGA VQVPLFDPDITSDYHSPVDHEDISV SAQTLSISRSVSTNMDTRRLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
