Recombinant Human KDR, Fc-His
Cat.No. : | KDR-1697H |
Product Overview : | Recombinant Human VEGFR2 encoding amino acid residues 1 - 764 of the extracellular domain of human VEGFR2 was fused to a 6X His-tagged Fc of human IgG1 via the peptide (IEGRMD). It was expressed inNSO Cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | KDR-1697H |
Description : | Vascular endothelial growth factor receptor 2 (VEGF R2) is a transmembrane glycoprotein that is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration, and differentiation. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >90% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human KDR is Mr 110 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 160-170 kDa. |
Biological Activity : | The biological activity of Human KDR was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The expected ED50 for this effect is typically 4-8 ng/ml in the presence of 5 ng/ml recombinant human VEGF165. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ] |
Synonyms : | KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; EC 2.7.10.1; fetal liver kinase-1; soluble VEGFR2; tyrosine kinase growth factor receptor |
Gene ID : | 3791 |
mRNA Refseq : | NM_002253 |
Protein Refseq : | NP_002244 |
MIM : | 191306 |
UniProt ID : | P35968 |
Chromosome Location : | 4q11-q12 |
Pathway : | Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; VEGF signaling pathway; Signaling by VEGF |
Function : | ATP binding; growth factor binding; nucleotide binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity |
Products Types
◆ Lysates | ||
KDR-1769HCL | Recombinant Human KDR cell lysate | +Inquiry |
KDR-417HCL | Recombinant Human KDR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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