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Recombinant Human KDR Protein, His-tagged

Cat.No. : KDR-475H
Product Overview : Recombinant human KDR protein with His tag was expressed in HEK293.
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Description : Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized
Molecular Mass : 86.2 kDa
Protein Length : 1356
AA Sequence : MQSKVLLAVALWLCVETRAASVGLP SVSLDLPRLSIQKDILTIKANTTLQ ITCRGQRDLDWLWPNNQSGSEQRVE VTECSDGLFCKTLTIPKVIGNDTGA YKCFYRETDLASVIYVYVQDYRSPF IASVSDQHGVVYITENKNKTVVIPC LGSISNLNVSLCARYPEKRFVPDGN RISWDSKKGFTIPSYMISYAGMVFC EAKINDESYQSIMYIVVVVGYRIYD VVLSPSHGIELSVGEKLVLNCTART ELNVGIDFNWEYPSSKHQHKKLVNR DLKTQSGSEMKKFLSTLTIDGVTRS DQGLYTCAASSGLMTKKNSTFVRVH EKPFVAFGSGMESLVEATVGERVRI PAKYLGYPPPEIKWYKNGIPLESNH TIKAGHVLTIMEVSERDTGNYTVIL TNPISKEKQSHVVSLVVYVPPQIGE KSLISPVDSYQYGTTQTLTCTVYAI PPPHHIHWYWQLEEECANEPSQAVS VTNPYPCEEWRSVEDFQGGNKIEVN KNQFALIEGKNKTVSTLVIQAANVS ALYKCEAVNKVGRGERVISFHVTRG PEITLQPDMQPTEQESVSLWCTADR STFENLTWYKLGPQPLPIHVGELPT PVCKNLDTLWKLNATMFSNSTNDIL IMELKNASLQDQGDYVCLAQDRKTK KRHCVVRQLTVLERVAPTITGNLEN QTTSIGESIEVSCTASGNPPPQIMW FKDNETLVEDSGIVLKDGNRNLTIR RVRKEDEGLYTCQACSVLGCAKVEA FFIIEGAQEKTNLEIIILVGTAVIA MFFWLLLVIILRTVKRANGGELKTG YLSIVMDPDELPLDEHCERLPYDAS KWEFPRDRLKLGKPLGRGAFGQVIE ADAFGIDKTATCRTVAVKMLKEGAT HSEHRALMSELKILIHIGHHLNVVN LLGACTKPGGPLMVIVEFCKFGNLS TYLRSKRNEFVPYKTKGARFRQGKD YVGAIPVDLKRRLDSITSSQSSASS GFVEEKSLSDVEEEEAPEDLYKDFL TLEHLICYSFQVAKGMEFLASRKCI HRDLAARNILLSEKNVVKICDFGLA RDIYKDPDYVRKGDARLPLKWMAPE TIFDRVYTIQSDVWSFGVLLWEIFS LGASPYPGVKIDEEFCRRLKEGTRM RAPDYTTPEMYQTMLDCWHGEPSQR PTFSELVEHLGNLLQANAQQDGKDY IVLPISETLSMEEDSGLSLPTSPVS CMEEEEVCDPKFHYDNTAGISQYLQ NSKRKSRPVSVKTFEDIPLEEPEVK VIPDDNQTDSGMVLASEELKTLEDR TKLSPSFGGMVPSKSRESVASEGSN QTSGYQSGYHSDDTDTTVYSSEEAE LLKLIEIGVQTGSTAQILQPDSGTT LSSPPV
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens (human) ]
Official Symbol : KDR
Synonyms : KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor;
Gene ID : 3791
mRNA Refseq : NM_002253
Protein Refseq : NP_002244
MIM : 191306
UniProt ID : P35968

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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