| Description : |
The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
85.3 kDa |
| AA Sequence : |
MKPFQLDLLFVCFFLFSQELGLQKR GCCLVLGYMAKDKFRRMNEGQVYSF SQQPQDQVVVSGQPVTLLCAIPEYD GFVLWIKDGLALGVGRDLSSYPQYL VVGNHLSGEHHLKILRAELQDDAVY ECQAIQAAIRSRPARLTVLVPPDDP VILGGPVISLRAGDPLNLTCHADNA KPAASIIWLRKGEVINGATYSKTLL RDGKRESIVSTLFISPGDVENGQSI VCRATNKAIPGGKETSVTIDIQHPP LVNLSVEPQPVLEDNVVTFHCSAKA NPAVTQYRWAKRGQIIKEASGEVYR TTVDYTYFSEPVSCEVTNALGSTNL SRTVDVYFGPRMTTEPQSLLVDLGS DAIFSCAWTGNPSLTIVWMKRGSGV VLSNEKTLTLKSVRQEDAGKYVCRA VVPRVGAGEREVTLTVNGPPIISST QTQHALHGEKGQIKCFIRSTPPPDR IAWSWKENVLESGTSGRYTVETIST EEGVISTLTISNIVRADFQTIYNCT AWNSFGSDTEIIRLKEQGSEMKSGA GLEAESVPMAVIIGVAVGAGVAFLV LMATIVAFCCARSQRNLKGVVSAKN DIRVEIVHKEPASGREGEEHSTIKQ LMMDRGEFQQDSVLKQLEVLKEEEK EFQNLKDPTNGYYSVNTFKEHHSTP TISLSSCQPDLRPAGKQRVPTGMSF TNIYSTLSGQGRLYDYGQRFVLGMG SSSIELCEREFQRGSLSDSSSFLDT QCDSSVSSSGKQDGYVQFDKASKAS ASSSHHSQSSSQNSDPSRPLQRRMQ THVTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
