Recombinant Human KLHL12 Protein, GST/His-tagged

• Cat.No.: KLHL12-615H
• Product Overview: Recombinant human KLHL12 protein, fused to GST at N-terminusand His at C-terminusand, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Description: This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
• Form: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
• Molecular Mass: 91.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: kelch like family member 12[ Homo sapiens ]
• Official Symbol: KLHL12
• Synonyms: C3IP1; DKIR
• Gene ID: 59349
• mRNA Refseq: NM_021633.2
• Protein Refseq: NP_067646.1
• MIM: 614522
• UniProt ID: Q53G59