Recombinant Human KMO Protein, MYC/DDK-tagged

• Cat.No.: KMO-516H
• Product Overview: Recombinant Human KMO fused with MYC/DDK tag at C-terminal was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
• Form: 25 mM Tris-HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 61.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) [ Homo sapiens ]
• Official Symbol: KMO
• Synonyms: KMO; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase); kynurenine 3-monooxygenase; kynurenine 3-hydroxylase; dJ317G22.1
• Gene ID: 8564
• mRNA Refseq: NM_003679
• Protein Refseq: NP_003670
• MIM: 603538
• UniProt ID: O15229