Recombinant Human KMT2D Complex, His-tagged

• Cat.No.: KMT2D-129H
• Product Overview: Recombinant Human MLL2(5319-5537), WDR5(22-334), RbBP5(1-538), Ash2L(2-534), DPY-30(1-99) protein, fused with N-terminal His-tag on all subunits, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Form: 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP (tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM ZnCl2.
• Molecular Mass: 211.0 kDa
• Purity: >90% by SDS-PAGE
• Storage: Store at -80°C. Thaw quickly and store on ice before use. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: KMT2D lysine (K)-specific methyltransferase 2D [ Homo sapiens ]
• Official Symbol: KMT2D
• Synonyms: ALR; KMS; MLL2; MLL4; AAD10; KABUK1; TNRC21; CAGL114; ALL1-related protein; Kabuki make-up syndrome; Kabuki mental retardation syndrome; histone-lysine N-methyltransferase MLL2; lysine N-methyltransferase 2D; myeloid/lymphoid or mixed-lineage leukemia 2; trinucleotide repeat containing 21
• Gene ID: 8085
• mRNA Refseq: NM_003482
• Protein Refseq: NP_003473
• MIM: 602113
• UniProt ID: O14686
• Chromosome Location: 12q13.12
• Pathway: Chromatin modifying enzymes, organism-specific biosystem; Deactivation of the beta-catenin transactivating complex, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem
• Function: DNA binding; histone methyltransferase activity (H3-K4 specific); protein binding