Recombinant Human KNL1 Protein, GST-Tagged
Cat.No. : | KNL1-0410H |
Product Overview : | Human CASC5 partial ORF (NP_733468, 3 a.a. - 98 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.3 kDa |
AA Sequence : | GVSSEANEENDNIERPVRRRHSSIL KPPRSPLQDHRGGNERVQESNALRN KKNSRRVSFADTIKVFQTESHMKIV RKSEMEGCSAMVPSQLQLLPP |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | KNL1 kinetochore scaffold 1 [ Homo sapiens (human) ] |
Official Symbol : | KNL1 |
Synonyms : | KNL1; kinetochore scaffold 1; CASC5; cancer susceptibility candidate 5; protein CASC5; AF15Q14; blinkin; bub linking kinetochore protein; cancer/testis antigen 29; CT29; D40; hKNL 1; hSpc105; kinetochore null 1 homolog (C. elegans); KNL1; PPP1R55; protein phosphatase 1; regulatory subunit 55; kinetochore null 1 homolog; kinetochore-null protein 1; bub-linking kinetochore protein; blinkin, bub-linking kinetochore protein; protein phosphatase 1, regulatory subunit 55; ALL1-fused gene from chromosome 15q14 protein; cancer susceptibility candidate gene 5 protein; hKNL-1; KIAA1570; |
Gene ID : | 57082 |
mRNA Refseq : | NM_144508 |
Protein Refseq : | NP_653091 |
MIM : | 609173 |
UniProt ID : | Q8NG31 |
Products Types
◆ Recombinant Protein | ||
Knl1-1723M | Recombinant Mouse Knl1 protein, His & T7-tagged | +Inquiry |
KNL1-3165H | Recombinant Human KNL1 protein, His-tagged | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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