Recombinant Human KREMEN1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: KREMEN1-2847H
• Product Overview: KREMEN1 MS Standard C13 and N15-labeled recombinant protein (NP_001034660) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 50.18 kDa
• AA Sequence: MAPPAARLALLSAAALTLAARPAPS PGLGPGPECFTANGADYRGTQNWTA LQGGKPCLFWNETFQHPYNTLKYPN GEGGLGEHNYCRNPDGDVSPWCYVA EHEDGVYWKYCEIPACQMPGNLGCY KDHGNPPPLTGTSKTSNKLTIQTCI SFCRSQRFKFAGMESGYACFCGNNP DYWKYGEAASTECNSVCFGDHTQPC GGDGRIILFDTLVGACGGNYSAMSS VVYSPDFPDTYATGRVCYWTIRVPG ASHIHFSFPLFDIRDSADMVELLDG YTHRVLARFHGRSRPPLSFNVSLDF VILYFFSDRINQAQGFAVLYQAVKE ELPQERPAVNQTVAEVITEQANLSV SAARSSKVLYVITTSPSHPPQTVPG WTVYGLATLLILTVTAIVAKILLHV TFKSHRVPASGDLRDCHQPGTSGEI WSIFYKPSTSISIFKKKLKGQSQQD DRNPLVSDTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: KREMEN1 kringle containing transmembrane protein 1 [ Homo sapiens (human) ]
• Official Symbol: KREMEN1
• Synonyms: KREMEN1; kringle containing transmembrane protein 1; KREMEN, kringle containing transmembrane protein; kremen protein 1; KRM1; dickkopf receptor; kringle-coding gene marking the eye and the nose; kringle domain-containing transmembrane protein 1; kringle-containing protein marking the eye and the nose; KREMEN; FLJ31863
• Gene ID: 83999
• mRNA Refseq: NM_001039571
• Protein Refseq: NP_001034660
• MIM: 609898
• UniProt ID: Q96MU8