Recombinant Human LANCL1, His-tagged

• Cat.No.: LANCL1-243H
• Product Overview: LANCL1, 1-399aa, Human, His tag, E.coli

Specification

• Description: LANCL1 is a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. Recombinant human LANCL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 7.5) containing 0.15M NaCl, 20% glycerol, 1mM DTT
• Molecular Mass: 47.7 kDa (422aa) confirmed by MALDI-TOF
• Protein length: 1-399aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAQRAFP NPYADYNKSL AEGYFDAAGR LTPEFSQRLT NKIRELLQQM ERGLKSADPR DGTGYTGWAG IAVLYLHLYD VFGDPAYLQL AHGYVKQSLN CLTKRSITFL CGDAGPLAVA AVLYHKMNNE KQAEDCITRL IHLNKIDPHA PNEMLYGRIG YIYALLFVNK NFGVEKIPQS HIQQICETIL TSGENLARKR NFTAKSPLMY EWYQEYYVGA AHGLAGIYYY LMQPSLQVSQ GKLHSLVKPS VDYVCQLKFP SGNYPPCIGD NRDLLVHWCH GAPGVIYMLI QAYKVFREEK YLCDAYQCAD VIWQYGLLKK GYGLCHGSAG NAYAFLTLYN LTQDMKYLYR ACKFAEWCLE YGEHGCRTPD TPFSLFEGMA GTIYFLADLL VPTKARFPAF EL
• Purity: >95 % by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) [ Homo sapiens ]
• Official Symbol: LANCL1
• Synonyms: LANCL1; LanC lantibiotic synthetase component C-like 1 (bacterial); GPR69A, LanC (bacterial lantibiotic synthetase component C) like 1; lanC-like protein 1; p40; G protein-coupled receptor 69A; 40 kDa erythrocyte membrane protein; LanC (bacterial lantibiotic synthetase component); LanC (bacterial lantibiotic synthetase component C)-like 1; GPR69A
• Gene ID: 10314
• mRNA Refseq: NM_001136574
• Protein Refseq: NP_001130046
• MIM: 604155
• UniProt ID: O43813
• Chromosome Location: 2q33-q35
• Function: G-protein coupled receptor activity; SH3 domain binding; catalytic activity; glutathione binding; low-density lipoprotein particle receptor binding; metal ion binding; zinc ion binding