| Description : |
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
156.9 kDa |
| AA Sequence : |
MRQVLWLCNVCVTARETRHHLHLPA ILDKMPAPGALILLAAVSASGCLAS PAHPDGFALGRAPLAPPYAVVLISC SGLLAFIFLLLTCLCCKRGDVGFKE FENPEGEDCSGEYTPPAEETSSSQS LPDVYILPLAEVSLPMPAPQPSHSD MTTPLGLSRQHLSYLQEIGSGWFGK VILGEIFSDYTPAQVVVKELRASAG PLEQRKFISEAQPYRSLQHPNVLQC LGLCVETLPFLLIMEFCQLGDLKRY LRAQRPPEGLSPELPPRDLRTLQRM GLEIARGLAHLHSHNYVHSDLALRN CLLTSDLTVRIGDYGLAHSNYKEDY YLTPERLWIPLRWAAPELLGELHGT FMVVDQSRESNIWSLGVTLWELFEF GAQPYRHLSDEEVLAFVVRQQHVKL ARPRLKLPYADYWYDILQSCWRPPA QRPSASDLQLQLTYLLSERPPRPPP PPPPPRDGPFPWPWPPAHSAPRPGT LSSPFPLLDGFPGADPDDVLTVTES SRGLNLECLWEKARRGAGRGGGAPA WQPASAPPAPHANPSNPFYEALSTP SVLPVISARSPSVSSEYYIRLEEHG SPPEPLFPNDWDPLDPGVPAPQAPQ APSEVPQLVSETWASPLFPAPRPFP AQSSASGSFLLSGWDPEGRGAGETL AGDPAEVLGERGTAPWVEEEEEEEE GSSPGEDSSSLGGGPSRRGPLPCPL CSREGACSCLPLERGDAVAGWGGHP ALGCPHPPEDDSSLRAERGSLADLP MAPPASAPPEFLDPLMGAAAPQYPG RGPPPAPPPPPPPPRAPADPAASPD PPSAVASPGSGLSSPGPKPGDSGYE TETPFSPEGAFPGGGAAEEEGVPRP RAPPEPPDPGAPRPPPDPGPLPLPG PREKPTFVVQVSTEQLLMSLREDVT RNLLGEKGATARETGPRKAGRGPGN REKVPGLNRDPTVLGNGKQAPSLSL PVNGVTVLENGDQRAPGIEEKAAEN GALGSPEREEKVLENGELTPPRREE KALENGELRSPEAGEKVLVNGGLTP PKSEDKVSENGGLRFPRNTERPPET GPWRAPGPWEKTPESWGPAPTIGEP APETSLERAPAPSAVVSSRNGGETA PGPLGPAPKNGTLEPGTERRAPETG GAPRAPGAGRLDLGSGGRAPVGTGT APGGGPGSGVDAKAGWVDNTRPQPP PPPLPPPPEAQPRRLEPAPPRARPE VAPEGEPGAPDSRAGGDTALSGDGD PPKPERKGPEMPRLFLDLGPPQGNS EQIKARLSRLSLALPPLTLTPFPGP GPRRPPWEGADAGAAGGEAGGAGAP GPAEEDGEDEDEDEEEDEEAAAPGA AAGPRGPGRARAAPVPVVVSSADAD AARPLRGLLKSPRGADEPEDSELER KRKMVSFHGDVTVYLFDQETPTNEL SVQAPPEGDTDPSTPPAPPTPPHPA TPGDGFPSNDSGFGGSFEWAEDFPL LPPPGPPLCFSRFSVSPALETPGPP ARAPDARPAGPVENTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
