Recombinant Human LOX protein, GST-tagged

• Cat.No.: LOX-189H
• Product Overview: Recombinant Human LOX(169-end) fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 169-417 aa
• Description: LOX or lysyl oxidase is an extracellular copper enzyme that initiates the cross-linking of collagens and elastin. LOX catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. LOX plays an important role in tumor suppression. LOX may be required to create a niche permissive for metastatic growth and it is essential for hypoxia-induced metastasis.
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: 57 kDa
• Purity: > 70 %
• Stability: 1 year at - 70 centigrade from date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05μg/μl

Gene Information

• Gene Name: LOX lysyl oxidase [ Homo sapiens ]
• Official Symbol: LOX
• Synonyms: LOX; lysyl oxidase; protein-lysine 6-oxidase; MGC105112
• Gene ID: 4015
• mRNA Refseq: NM_001178102
• Protein Refseq: NP_001171573
• MIM: 153455
• UniProt ID: P28300
• Chromosome Location: 5q23.3-q31.2
• Function: copper ion binding; metal ion binding; oxidoreductase activity; protein-lysine 6-oxidase activity