| Description : |
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptake of the drug cisplatin. Mediates the import of the antibiotic blasticidin-S into the cell. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
98.2 kDa |
| AA Sequence : |
MFTLAEVASLNDIQPTYRILKPWWD VFMDYLAVVMLMVAIFAGTMQLTKD QVVCLPVLPSPVNSKAHTPPGNAEV TTNIPKMEAATNQDQDGRTTNDISF GTSAVTPDIPLRATYPRTDFALPNQ EAKKEKKDPTGRKTNLDFQQYVFIN QMCYHLALPWYSKYFPYLALIHTII LMVSSNFWFKYPKTCSKVEHFVSIL GKCFESPWTTKALSETACEDSEENK QRITGAQTLPKHVSTSSDEGSPSAS TPMINKTGFKFSAEKPVIEVPSMTI LDKKDGEQAKALFEKVRKFRAHVED SDLIYKLYVVQTVIKTAKFIFILCY TANFVNAISFEHVCKPKVEHLIGYE VFECTHNMAYMLKKLLISYISIICV YGFICLYTLFWLFRIPLKEYSFEKV REESSFSDIPDVKNDFAFLLHMVDQ YDQLYSKRFGVFLSEVSENKLREIS LNHEWTFEKLRQHISRNAQDKQELH LFMLSGVPDAVFDLTDLDVLKLELI PEAKIPAKISQMTNLQELHLCHCPA KVEQTAFSFLRDHLRCLHVKFTDVA EIPAWVYLLKNLRELYLIGNLNSEN NKMIGLESLRELRHLKILHVKSNLT KVPSNITDVAPHLTKLVIHNDGTKL LVLNSLKKMMNVAELELQNCELERI PHAIFSLSNLQELDLKSNNIRTIEE IISFQHLKRLTCLKLWHNKIVTIPP SITHVKNLESLYFSNNKLESLPVAV FSLQKLRCLDVSYNNISMIPIEIGL LQNLQHLHITGNKVDILPKQLFKCI KLRTLNLGQNCITSLPEKVGQLSQL TQLELKGNCLDRLPAQLGQCRMLKK SGLVVEDHLFDTLPLEVKEALNQDI NIPFANGITRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
