Recombinant Human LRRFIP1 Protein (1-314 aa), His-tagged

• Cat.No.: LRRFIP1-634H
• Product Overview: Recombinant Human LRRFIP1 Protein (1-314 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Transcription. Protein Description: Partial.

Specification

• Description: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 40.1 kDa
• Protein length: 1-314 aa
• AA Sequence: MTSPAAAQSREIDCLSPEAQKLAEA RLAAKRAARAEAREIRMKELERQQK EVEERPEKDFTEKGSRNMPGLSAAT LASLGGTSSRRGSGDTSISIDTEAS IREIKDSLAEVEEKYKKAMVSNAQL DNEKTNFMYQVDTLKDMLLELEEQL AESRRQYEEKNKEFEREKHAHSILQ FQFAEVKEALKQREEMLEKHGIILN SEIATNGETSDTLNNVGYQGPTKMT KEELNALKSTGDGTLGRASEVEVKN EIVANVGKREILHNTEKEQHTEDTV KDCVDIEVFPAGENTEDQKSSEDTA PFLGTLAGATYEEQSLSTCSLDR
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 [ Homo sapiens ]
• Official Symbol: LRRFIP1
• Synonyms: LRRFIP1; FLAP 1; FLIIAP1; GCF 2; HUFI 1; TRIP; GCF2; FLAP1; GCF-2; FLAP-1; HUFI-1; MGC10947; MGC119738; MGC119739
• Gene ID: 9208
• mRNA Refseq: NM_001137550
• Protein Refseq: NP_001131022
• MIM: 603256
• UniProt ID: Q32MZ4