| Description : |
The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
72.8 kDa |
| AA Sequence : |
MAIVQTLPVPLEPAPEAATAPQAPV MGSVSSLISGRPCPGGPAPPRHHGP PGPTFFRQQDGLLRGGYEAQEPLCP AVPPRKAVPVTSFTYINEDFRTESP PSPSSDVEDAREQRAHNAHLRGPPP KLIPVSGKLEKNMEKILIRPTAFKP VLPKPRGAPSLPSFMGPRATGLSGS QGSLTQLFGGPASSSSSSSSSSAAD KPLAFSGWASGCPSGTLSDSGRNSL SSLPTYSTGGAEPTTSSPGGHLPSH GSGRGALPGPARGVPTGPSHSDSGR SSSSKSTGSLGGRVAGGLLGSGTRA SPDSSSCGERSPPPPPPPPSDEALL HCVLEGKLRDREAELQQLRDSLDEN EATMCQAYEERQRHWQREREALRED CAAQAQRAQRAQQLLQLQVFQLQQE KRQLQDDFAQLLQEREQLERRCATL EREQRELGPRLEETKWEVCQKSGEI SLLKQQLKESQAELVQKGSELVALR VALREARATLRVSEGRARGLQEAAR ARELELEACSQELQRHRQEAEQLRE KAGQLDAEAAGLREPPVPPATADPF LLAESDEAKVQRAAAGVGGSLRAQV ERLRVELQRERRRGEEQRDSFEGER LAWQAEKEQVIRYQKQLQHNYIQMY RRNRQLEQELQQLSLELEARELADL GLAEQAPCICLEEITATEITRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
