Recombinant Human MARK1 Protein (N45-L795), Tag Free

• Cat.No.: MARK1-1196H
• Product Overview: Recombinant Human MARK1(N45-L795 end) (ΔS383-S681) (K761S, R764S) Protein was expressed in E. coli.

Specification

• Description: Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
• Source: E. coli
• Species: Human
• Tag: No tag
• Form: Liquid
• Protein Length: N45-L795
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: MARK1 MAP/microtubule affinity-regulating kinase 1 [ Homo sapiens (human) ]
• Official Symbol: MARK1
• Synonyms: MARK1; MAP/microtubule affinity-regulating kinase 1; serine/threonine-protein kinase MARK1; MARK; PAR1 homolog c; Par1c; Par-1c; KIAA1477; MGC126512; MGC126513
• Gene ID: 4139
• mRNA Refseq: NM_018650
• Protein Refseq: NP_061120
• MIM: 606511
• UniProt ID: Q9P0L2