| Description : |
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
81.9 kDa |
| AA Sequence : |
MRWLLLYYALCFSLSKASAHTVELN NMFGQIQSPGYPDSYPSDSEVTWNI TVPDGFRIKLYFMHFNLESSYLCEY DYVKVETEDQVLATFCGRETTDTEQ TPGQEVVLSPGSFMSITFRSDFSNE ERFTGFDAHYMAVDVDECKEREDEE LSCDHYCHNYIGGYYCSCRFGYILH TDNRTCRVECSDNLFTQRTGVITSP DFPNPYPKSSECLYTIELEEGFMVN LQFEDIFDIEDHPEVPCPYDYIKIK VGPKVLGPFCGEKAPEPISTQSHSV LILFHSDNSGENRGWRLSYRAAGNE CPELQPPVHGKIEPSQAKYFFKDQV LVSCDTGYKVLKDNVEMDTFQIECL KDGTWSNKIPTCKIVDCRAPGELEH GLITFSTRNNLTTYKSEIKYSCQEP YYKMLNNNTGIYTCSAQGVWMNKVL GRSLPTCLPECGQPSRSLPSLVKRI IGGRNAEPGLFPWQALIVVEDTSRV PNDKWFGSGALLSASWILTAAHVLR SQRRDTTVIPVSKEHVTVYLGLHDV RDKSGAVNSSAARVVLHPDFNIQNY NHDIALVQLQEPVPLGPHVMPVCLP RLEPEGPAPHMLGLVAGWGISNPNV TVDEIISSGTRTLSDVLQYVKLPVV PHAECKTSYESRSGNYSVTENMFCA GYYEGGKDTCLGDSGGAFVIFDDLS QRWVVQGLVSWGGPEECGSKQVYGV YTKVSNYVDWVWEQMGLPQSVVEPQ VERTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
