Description : |
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
79.25 kDa |
AA Sequence : |
MRWLLLYYALCFSLSKASAHTVELN NMFGQIQSPGYPDSYPSDSEVTWNI TVPDGFRIKLYFMHFNLESSYLCEY DYVKVETEDQVLATFCGRETTDTEQ TPGQEVVLSPGSFMSITFRSDFSNE ERFTGFDAHYMAVDVDECKEREDEE LSCDHYCHNYIGGYYCSCRFGYILH TDNRTCRVECSDNLFTQRTGVITSP DFPNPYPKSSECLYTIELEEGFMVN LQFEDIFDIEDHPEVPCPYDYIKIK VGPKVLGPFCGEKAPEPISTQSHSV LILFHSDNSGENRGWRLSYRAAGNE CPELQPPVHGKIEPSQAKYFFKDQV LVSCDTGYKVLKDNVEMDTFQIECL KDGTWSNKIPTCKIVDCRAPGELEH GLITFSTRNNLTTYKSEIKYSCQEP YYKMLNNNTGIYTCSAQGVWMNKVL GRSLPTCLPVCGLPKFSRKLMARIF NGRPAQKGTTPWIAMLSHLNGQPFC GGSLLGSSWIVTAAHCLHQSLDPED PTLRDSDLLSPSDFKIILGKHWRLR SDENEQHLGVKHTTLHPQYDPNTFE NDVALVELLESPVLNAFVMPICLPE GPQQEGAMVIVSGWGKQFLQRFPET LMEIEIPIVDHSTCQKAYAPLKKKV TRDMICAGEKEGGKDACAGDSGGPM VTLNRERGQWYLVGTVSWGDDCGKK DRYGVYSYIHHNKDWIQRVTGVRNT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |