Recombinant Human MAT2A Protein, His-tagged
Cat.No. : | MAT2A-490H |
Product Overview : | Recombinant Human MAT2A(Leu176~Tyr395) fused with His tag at N-terminal was expressed in E. coli. |
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Description : | The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Molecular Mass : | 28.4kDa |
Protein length : | Leu176~Tyr395 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 92% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others. |
Gene Name : | MAT2A methionine adenosyltransferase II, alpha [ Homo sapiens ] |
Official Symbol : | MAT2A |
Synonyms : | MAT2A; methionine adenosyltransferase II, alpha; S-adenosylmethionine synthase isoform type-2; MATA2; MATII; SAMS2; MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; |
Gene ID : | 4144 |
mRNA Refseq : | NM_005911 |
Protein Refseq : | NP_005902 |
MIM : | 601468 |
UniProt ID : | P31153 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, dysregulation of MAT2A expression has been associated with certain cancers. Understanding its role in cancer metabolism could lead to targeted therapies.
In theory, inhibiting MAT2A could alter cellular methylation patterns, making it a potential strategy for disorders characterized by abnormal methylation.
MAT2A influences cellular methylation patterns by providing SAMe, a methyl donor essential for the methylation of proteins, lipids, and nucleic acids.
SAMe, produced by MAT2A, is a precursor for neurotransmitter synthesis. Altered MAT2A function may have implications for neurological disorders like depression and schizophrenia.
MAT2A-derived SAMe is essential for DNA methylation. Aberrant DNA methylation is a hallmark of cancer, and targeting MAT2A may have implications for epigenetic cancer therapies.
Customer Reviews (3)
Write a reviewIts exceptional reliability and compatibility with various research methodologies make it an invaluable asset for scientists seeking to delve into protein-protein interactions, signaling pathways, and structural investigations.
Incorporating the ARRB2A protein into research endeavors ensures accurate and comprehensive results, bringing us closer to unraveling the complexities of cellular processes.
Its robust nature and stability make it suitable for imaging studies, providing researchers with a detailed understanding of the protein's structural characteristics.
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