Recombinant Human MDH2 Protein, GST-tagged
Cat.No. : | MDH2-4498H |
Product Overview : | Human MDH2 full-length ORF ( NP_005909.2, 1 a.a. - 338 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 61.9 kDa |
AA Sequence : | MLSALARPASAALRRSFSTSAQNNA KVAVLGASGGIGQPLSLLLKNSPLV SRLTLYDIAHTPGVAADLSHIETKA AVKGYLGPEQLPDCLKGCDVVVIPA GVPRKPGMTRDDLFNTNATIVATLT AACAQHCPEAMICVIANPVNSTIPI TAEVFKKHGVYNPNKIFGVTTLDIV RANTFVAELKGLDPARVNVPVIGGH AGKTIIPLISQCTPKVDFPQDQLTA LTGRIQEAGTEVVKAKAGAGSATLS MAYAGARFVFSLVDAMNGKEGVVEC SFVKSQETECTYFSTPLLLGKKGIE KNLGIGKVSSFEEKMISDAIPELKA SIKKGEDFVKTLK |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | MDH2 malate dehydrogenase 2, NAD (mitochondrial) [ Homo sapiens ] |
Official Symbol : | MDH2 |
Synonyms : | MDH2; malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; MDH; MOR1; M-MDH; MGC:3559; |
Gene ID : | 4191 |
mRNA Refseq : | NM_005918 |
Protein Refseq : | NP_005909 |
MIM : | 154100 |
UniProt ID : | P40926 |
Products Types
◆ Recombinant Protein | ||
MDH2-4499H | Active Recombinant Human MDH2 Protein, His-tagged | +Inquiry |
Mdh2-4004M | Recombinant Mouse Mdh2 Protein, Myc/DDK-tagged | +Inquiry |
MDH2-3285R | Recombinant Rat MDH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MDH2-5432M | Recombinant Mouse MDH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MDH2-426C | Recombinant Cynomolgus Monkey MDH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MDH2-4407HCL | Recombinant Human MDH2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-0545 | Malate Dehydrogenase 2 Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (5)
Ask a questionCurrently, there are no specific drugs targeting MDH2 approved for clinical use, but research is ongoing to explore potential therapeutic interventions.
Emerging research suggests a potential link between MDH2 dysfunction and neurodegenerative diseases, opening avenues for further investigation.
Abnormal MDH2 expression is observed in some cancer types, suggesting its potential role as a diagnostic or therapeutic target in cancer treatment.
MDH2 participates in the citric acid cycle, facilitating the conversion of malate to oxaloacetate and contributing to the production of ATP in the mitochondria.
Yes, altered MDH2 levels can serve as a biomarker for metabolic diseases, aiding in early detection and monitoring of these conditions.
Customer Reviews (3)
Write a reviewIts ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.
The use of MDH2 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.
The manufacturer of MDH2 protein plays a crucial role in supporting my research endeavors.
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