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Recombinant Human MDH2 Protein, GST-tagged

Cat.No. : MDH2-4498H
Product Overview : Human MDH2 full-length ORF ( NP_005909.2, 1 a.a. - 338 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 61.9 kDa
AA Sequence : MLSALARPASAALRRSFSTSAQNNA KVAVLGASGGIGQPLSLLLKNSPLV SRLTLYDIAHTPGVAADLSHIETKA AVKGYLGPEQLPDCLKGCDVVVIPA GVPRKPGMTRDDLFNTNATIVATLT AACAQHCPEAMICVIANPVNSTIPI TAEVFKKHGVYNPNKIFGVTTLDIV RANTFVAELKGLDPARVNVPVIGGH AGKTIIPLISQCTPKVDFPQDQLTA LTGRIQEAGTEVVKAKAGAGSATLS MAYAGARFVFSLVDAMNGKEGVVEC SFVKSQETECTYFSTPLLLGKKGIE KNLGIGKVSSFEEKMISDAIPELKA SIKKGEDFVKTLK
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : MDH2 malate dehydrogenase 2, NAD (mitochondrial) [ Homo sapiens ]
Official Symbol : MDH2
Synonyms : MDH2; malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; MDH; MOR1; M-MDH; MGC:3559;
Gene ID : 4191
mRNA Refseq : NM_005918
Protein Refseq : NP_005909
MIM : 154100
UniProt ID : P40926

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific drugs targeting MDH2 in clinical use? 10/18/2020

Currently, there are no specific drugs targeting MDH2 approved for clinical use, but research is ongoing to explore potential therapeutic interventions.

Is MDH2 involved in neurodegenerative diseases? 06/09/2020

Emerging research suggests a potential link between MDH2 dysfunction and neurodegenerative diseases, opening avenues for further investigation.

How is MDH2 protein implicated in cancer? 06/09/2018

Abnormal MDH2 expression is observed in some cancer types, suggesting its potential role as a diagnostic or therapeutic target in cancer treatment.

How does MDH2 contribute to mitochondrial function? 09/16/2017

MDH2 participates in the citric acid cycle, facilitating the conversion of malate to oxaloacetate and contributing to the production of ATP in the mitochondria.

Can MDH2 protein be used as a biomarker for metabolic diseases? 01/21/2016

Yes, altered MDH2 levels can serve as a biomarker for metabolic diseases, aiding in early detection and monitoring of these conditions.

Customer Reviews (3)

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Reviews
07/02/2022

    Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

    01/18/2020

      The use of MDH2 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

      07/07/2019

        The manufacturer of MDH2 protein plays a crucial role in supporting my research endeavors.

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