Recombinant Human METTL3/METTL14 complex Protein, GST-tagged

• Cat.No.: METTL3-043H
• Product Overview: Full-length recombinant human METTL3/METTL14 complex was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
• Molecular Mass: 100 kDa (METTL3) and 84 kDa (METTL14)
• Purity: > 90%
• Applications: Activity Assay
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot targets into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM Glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit [ Homo sapiens (human) ]
• Official Symbol: METTL3
• Synonyms: METTL3; methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; M6A; IME4; Spo8; MT-A70; hMETTL3; N6-adenosine-methyltransferase catalytic subunit; N6-adenosine-methyltransferase 70 kDa subunit; adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; methyltransferase like 3; methyltransferase-like protein 3; EC 2.1.1.348
• Gene ID: ?term=56339
• mRNA Refseq: NM_019852
• Protein Refseq: NP_062826
• MIM: 612472
• UniProt ID: Q86U44