Recombinant Human MHC Class I Polypeptide-Related Sequence B

• Cat.No.: MICB-5194H
• Product Overview: Recombinant HumanMICB has 326 amino acid residues containing the extracellular domain ofmature human MICB (amino acid residues Ala23-Tyr312).

Specification

• Species: Human
• Source: Human
• Tag: Non
• Protein Length: 23-312 a.a.
• Description: This gene encodes aheavily glycosylated protein which is a ligand for the NKG2D type IIreceptor. Binding of the ligand activates the cytolytic response of naturalkiller (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which expressthe receptor. This protein is stress-induced and is similar to MHC class Imolecules; however, it does not associate with beta-2-microglobulin or bindpeptides.
• Form: Lyophilized from a0.2 μm sterile filtered solution of PBS, pH 7.0.
• Purity: >95% by SDS-PAGEand HPLC analyses.
• Molecular Weight: 37 kDa
• Biological Activity: Measured by itsability to bind MICB antibody in an ELISA.
• Endotoxin: < 0.1 ng/μg
• Reconstitution: Centrifugevial prior to opening. Add sterile distilled water or aqueousbuffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Please notethat the addition of any carrier protein into this product may produceunwanted endotoxin. This depends upon the particular application employed. Furtherdilutions should be made in appropriate buffered solutions.
• Storage: Stable at2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for up to1 week at 2-8°C. For longer term, store in working aliquots below -20°C. Avoidrepeated freeze/thaw cycles.
• OfficialSymbol: MICB
• Pathways: Adaptive ImmunitySignaling, Immune System, Immunoregulatory interactions between a Lymphoidand a non-Lymphoid cell, Natural killer cell mediated cytotoxicity

Gene Information

• Gene Name: MICB MHCclass I polypeptide-related sequence B [ Homo sapiens ]
• Synonyms: MICB; MHC class Ipolypeptide-related sequence B; PERB11.2; MICB; MIC-B; OTTHUMP00000029089;MHC class I polypeptide-related sequence B; MHC class I molecule; MHC class Imic-B antigen; stress inducible class I homolog; MHC class I chain-relatedprotein B; MHC class I-like molecule PERB11.2-IMX; OTTHUMP00000035091;TTHUMP00000035588
• Gene ID: 4277
• mRNA Refseq: NM_005931
• Protein Refseq: NP_005922
• MIM: 602436
• UniProt ID: Q29980
• Chromosome Location: 6p21.3
• Function: natural killer celllectin-like receptor binding