Recombinant Human MKNK1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MKNK1-3280H
• Product Overview: MKNK1 MS Standard C13 and N15-labeled recombinant protein (NP_003675) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 51.3 kDa
• AA Sequence: MVSSQKLEKPIEMGSSEPLPIADGD RRRKKKRRGRATDSLPGKFEDMYKL TSELLGEGAYAKVQGAVSLQNGKEY AVKIIEKQAGHSRSRVFREVETLYQ CQGNKNILELIEFFEDDTRFYLVFE KLQGGSILAHIQKQKHFNEREASRV VRDVAAALDFLHTKDKVSLCHLGWS AMAPSGLTAAPTSLGSSDPPTSASQ VAGTTGIAHRDLKPENILCESPEKV SPVKICDFDLGSGMKLNNSCTPITT PELTTPCGSAEYMAPEVVEVFTDQA TFYDKRCDLWSLGVVLYIMLSGYPP FVGHCGADCGWDRGEVCRVCQNKLF ESIQEGKYEFPDKDWAHISSEAKDL ISKLLVRDAKQRLSAAQVLQHPWVQ GQAPEKGLPTPQVLQRNSSTMDLTL FAAEAIALNRQLSQHEENELAEEPE ALADGLCSMKLSPPCKSRLARRRAL AQAGRGEDRSPPTALTRTRPLEQKL ISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MKNK1 MAP kinase interacting serine/threonine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: MKNK1
• Synonyms: MKNK1; MAP kinase interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MNK1; MAPK signal-integrating kinase 1; MAP kinase signal-integrating kinase 1
• Gene ID: 8569
• mRNA Refseq: NM_003684
• Protein Refseq: NP_003675
• MIM: 606724
• UniProt ID: Q9BUB5