"MLL3" Related Products

Recombinant Human MLL3 protein, GST-tagged, Active

Cat.No.: MLL3-191H
Product Overview: Recombinant Human MLL3(4689-end) fused with GST tag at N-terminal was expressed in Insect cells.
Description: Histone-lysine N-methyltransferase 2C, also known as mixed-lineage leukemia 2 (MLL3) is the central component of the MLL2/3 complex, a coactivator complex of nuclear receptors involved in transcriptional coactivation. Deletion of the region harboring the MLL3 gene was found to be the most frequently recurrent chromosomal abnormality in acute myeloid leukemia.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 1000 nmol/min/mg
Molecular Mass: 51 kDa
Protein length: 4689-end
Purity: >85%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: MLL3 myeloid/lymphoid or mixed-lineage leukemia 3 [ Homo sapiens ]
Official Symbol: MLL3
Synonyms: MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; histone-lysine N-methyltransferase MLL3; HALR; KIAA1506; KMT2C; ALR-like protein; homologous to ALR protein; lysine N-methyltransferase 2C; myeloid/lymphoid or mixed-lineage leukemia protein 3; histone-l
Gene ID: 58508
mRNA Refseq: NM_170606
Protein Refseq: NP_733751
MIM: 606833
UniProt ID: Q8NEZ4
Chromosome Location: 7q36
Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function: DNA binding; histone methyltransferase activity (H3-K4 specific); metal ion binding; methyltransferase activity; protein binding; transferase activity; zinc ion binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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