Recombinant Human MLPH Protein, GST-tagged

• Cat.No.: MLPH-5395H
• Product Overview: Human MLPH full-length ORF ( NP_077006.1, 1 a.a. - 600 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 92.3 kDa
• AA Sequence: MGKKLDLSKLTDEEAQHVLEVVQRD FDLRRKEEERLEALKGKIKKESSKR ELLSDTAHLNETHCARCLQPYQLLV NSKRQCLECGLFTCKSCGRVHPEEQ GWICDPCHLARVVKIGSLEWYYEHV KARFKRFGSAKVIRSLHGRLQGGAG PELISEERSGDSDQTDEDGEPGSEA QAQAQPFGSKKKRLLSVHDFDFEGD SDDSTQPQGHSLHLSSVPEARDSPQ SLTDESCSEKAAPHKAEGLEEADTG ASGCHSHPEEQPTSISPSRHGALAE LCPPGGSHRMALGTAAALGSNVIRN EQLPLQYLADVDTSDEESIRAHVMA SHHSKRRGRASSESQIFELNKHISA VECLLTYLENTVVPPLAKGLGAGVR TEADVEEEALRRKLEELTSNVSDQE TSSEEEEAKDEKAEPNRDKSVGPLP QADPEVGTAAHQTNRQEKSPQDPGD PVQYNRTTDEELSELEDRVAVTASE VQQAESEVSDIESRIAALRAAGLTV KPSGKPRRKSNLPIFLPRVAGKLGK RPEDPNADPSSEAKAMAVPYLLRRK FSNSLKSQGKDDDSFDRKSVYRGSL TQRNPNARKGMASHTFAKPVVAHQS
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MLPH melanophilin [ Homo sapiens ]
• Official Symbol: MLPH
• Synonyms: MLPH; melanophilin; exophilin 3; l(1) 3Rk; l1Rk3; ln; Slac 2a; exophilin-3; synaptotagmin-like protein 2a; slp homolog lacking C2 domains a; SLAC2-A; MGC2771; MGC59733
• Gene ID: 79083
• mRNA Refseq: NM_001042467
• Protein Refseq: NP_001035932
• MIM: 606526
• UniProt ID: Q9BV36