| Description : |
Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
78.6 kDa |
| AA Sequence : |
MNNFRATILFWAAAAWAKSGKPSGE MDEVGVQKCKNALKLPVLEVLPGGG WDNLRNVDMGRVMELTYSNCRTTED GQYIIPDEIFTIPQKQSNLEMNSEI LESWANYQSSTSYSINTELSLFSKV NGKFSTEFQRMKTLQVKDQAITTRV QVRNLVYTVKINPTLELSSGFRKEL LDISDRLENNQTRMATYLAELLVLN YGTHVTTSVDAGAALIQEDHLRASF LQDSQSSRSAVTASAGLAFQNTVNF KFEENYTSQNVLTKSYLSNRTNSRV QSIGGVPFYPGITLQAWQQGITNHL VAIDRSGLPLHFFINPNMLPDLPGP LVKKVSKTVETAVKRYYTFNTYPGC TDLNSPNFNFQANTDDGSCEGKMTN FSFGGVYQECTQLSGNRDVLLCQKL EQKNPLTGDFSCPSGYSPVHLLSQI HEEGYNHLECHRKCTLLVFCKTVCE DVFQVAKAEFRAFWCVASSQVPENS GLLFGGLFSSKSINPMTNAQSCPAG YFPLRLFENLKVCVSQDYELGSRFA VPFGGFFSCTVGNPLVDPAISRDLG ALSLKKCPGGFSQHPALISDGCQVS YCVKSGLFTGGSLPPARLPPFTRPP LMSQAATNTVIVTNSENARSWIKDS QTHQWRLGEPIELRRAMNVIHGDGG GLSGGAAAGVTVGVTTILAVVITLA IYGTRKFKKKAYQAIEERQSLVPGT AATGDTTYQEQGQSPATRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
