Recombinant Human MRC2

• Cat.No.: MRC2-29703TH
• Product Overview: Recombinant fragment corresponding to amino acids 105-214 of Human MRC2 protein with a proprietary tag; predicted mwt: 37.73 kDa.

Specification

• Description: MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al.
• Protein length: 110 amino acids
• Molecular Weight: 37.730kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: ASLGMYECDREALNLRWHCRTLGDQ LSLLLGARTSNISKPGTLERGDQTR SGQWRIYGSEEDLCALPYHEVYTIQ GNSHGKPCTIPFKYDNQWFHGCTST GREDGHLWCA
• Sequence Similarities: Contains 8 C-type lectin domains.Contains 1 fibronectin type-II domain.Contains 1 ricin B-type lectin domain.

Gene Information

• Gene Name: MRC2 mannose receptor, C type 2 [ Homo sapiens ]
• Official Symbol: MRC2
• Synonyms: MRC2; mannose receptor, C type 2; C-type mannose receptor 2; CD280; CLEC13E; ENDO180; KIAA0709
• Gene ID: 9902
• mRNA Refseq: NM_006039
• Protein Refseq: NP_006030
• MIM: 612264
• Uniprot ID: Q9UBG0
• Chromosome Location: 17q23
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystem
• Function: binding; receptor activity; sugar binding