Recombinant Human MSRB3, His-tagged

• Cat.No.: MSRB3-29917TH
• Product Overview: Recombinant full length Human MSRB3 with His tag, MWt 22.5 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula.
• Conjugation: HIS
• Tissue specificity: Widely expressed.
• Biological activity: Activity: 1 nmol of MSRB3-29917TH will reduce 2 nmol peptide-boundMet-S-sulfoxide in 1 min at 37°C.MetO-containing peptides are reduced by the enzyme in the presence of DTT.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 33% Glycerol, 0.1M Tris HCl, pH 7.4
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the MsrB Met sulfoxide reductase family.
• Full Length: Full L.

Gene Information

• Gene Name: MSRB3 methionine sulfoxide reductase B3 [ Homo sapiens ]
• Official Symbol: MSRB3
• Synonyms: MSRB3; methionine sulfoxide reductase B3; deafness, autosomal recessive 74 , DFNB74; methionine-R-sulfoxide reductase B3; DKFZp686C1178; FLJ36866
• Gene ID: 253827
• mRNA Refseq: NM_001031679
• Protein Refseq: NP_001026849
• MIM: 613719
• Uniprot ID: Q8IXL7
• Chromosome Location: 12q14.3
• Function: metal ion binding; oxidoreductase activity; peptide-methionine-(S)-S-oxide reductase activity; protein-methionine-R-oxide reductase activity; zinc ion binding