Recombinant Human MSTN Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MSTN-1851H
• Product Overview: MSTN MS Standard C13 and N15-labeled recombinant protein (NP_005250) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 42.8 kDa
• AA Sequence: MQKLQLCVYIYLFMLIVAGPVDLNE NSEQKENVEKEGLCNACTWRQNTKS SRIEAIKIQILSKLRLETAPNISKD VIRQLLPKAPPLRELIDQYDVQRDD SSDGSLEDDDYHATTETIITMPTES DFLMQVDGKPKCCFFKFSSKIQYNK VVKAQLWIYLRPVETPTTVFVQILR LIKPMKDGTRYTGIRSLKLDMNPGT GIWQSIDVKTVLQNWLKQPESNLGI EIKALDENGHDLAVTFPGPGEDGLN PFLEVKVTDTPKRSRRDFGLDCDEH STESRCCRYPLTVDFEAFGWDWIIA PKRYKANYCSGECEFVFLQKYPHTH LVHQANPRGSAGPCCTPTKMSPINM LYFNGKEQIIYGKIPAMVVDRCGCS TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MSTN myostatin [ Homo sapiens (human) ]
• Official Symbol: MSTN
• Synonyms: MSTN; myostatin; GDF8, growth differentiation factor 8; growth/differentiation factor 8; GDF-8; growth differentiation factor 8; GDF8; MSLHP
• Gene ID: 2660
• mRNA Refseq: NM_005259
• Protein Refseq: NP_005250
• MIM: 601788
• UniProt ID: O14793