| Description : |
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
81 kDa |
| AA Sequence : |
MGEHSPDNNIIYFEAEEDELTPDDK MLRFVDKNGLVPSSSGTVYDRTTVL IEQDPGTLEDEDDDGQCGEHLPFLV GGEEGFHLIDHEAMSQGYVQHIISP DQIHLTINPGSTPMPRNIEGATLTL QSECPETKRKEVKRYQCTFEGCPRT YSTAGNLRTHQKTHRGEYTFVCNQE GCGKAFLTSYSLRIHVRVHTKEKPF ECDVQGCEKAFNTLYRLKAHQRLHT GKTFNCESEGCSKYFTTLSDLRKHI RTHTGEKPFRCDHDGCGKAFAASHH LKTHVRTHTGERPFFCPSNGCEKTF STQYSLKSHMKGHDNKGHSYNALPQ HNGSEDTNHSLCLSDLSLLSTDSEL RENSSTTQGQDLSTISPAIIFESMF QNSDDTAIQEDPQQTASLTESFNGD AESVSDVPPSTGNSASLSLPLVLQP GLSEPPQPLLPASAPSAPPPAPSLG PGSQQAAFGNPPALLQPPEVPVPHS TQFAANHQEFLPHPQAPQPIVPGLS VVAGASASAAAVASAVAAPAPPQST TEPLPAMVQTLPLGANSVLTNNPTI TITPTPNTAILQSSLVMGEQNLQWI LNGATSSPQNQEQIQQASKVEKVFF TTAVPVASSPGSSVQQIGLSVPVII IKQEEACQCQCACRDSAKERASSRR KGCSSPPPPEPSPQAPDGPSLQLPA QTFSSAPVPGSSSSTLPSSCEQSRQ AETPSDPQTETLSAMDVSEFLSLQS LDTPSNLIPIEALLQGEEEMGLTSS FSKTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
