Description : |
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
101.5 kDa |
AA Sequence : |
MAPAEILNGKEISAQIRARLKNQVT QLKEQVPGFTPRLAILQVGNRDDSN LYINVKLKAAEEIGIKATHIKLPRT TTESEVMKYITSLNEDSTVHGFLVQ LPLDSENSINTEEVINAIAPEKDVD GLTSINAGRLARGDLNDCFIPCTPK GCLELIKETGVPIAGRHAVVVGRSK IVGAPMHDLLLWNNATVTTCHSKTA HLDEEVNKGDILVVATGQPEMVKGE WIKPGAIVIDCGINYVPDDKKPNGR KVVGDVAYDEAKERASFITPVPGGV GPMTVAMLMQSTVESAKRFLEKFKP GKWMIQYNNLNLKTPVPSDIDISRS CKPKPIGKLAREIGLLSEEVELYGE TKAKVLLSALERLKHRPDGKYVVVT GITPTPLGEGKSTTTIGLVQALGAH LYQNVFACVRQPSQGPTFGIKGGAA GGGYSQVIPMEEFNLHLTGDIHAIT AANNLVAAAIDARIFHELTQTDKAL FNRLVPSVNGVRRFSDIQIRRLKRL GIEKTDPTTLTDEEINRFARLDIDP ETITWQRVLDTNDRFLRKITIGQAP TEKGHTRTAQFDISVASEIMAVLAL TTSLEDMRERLGKMVVASSKKGEPV SAEDLGVSGALTVLMKDAIKPNLMQ TLEGTPVFVHAGPFANIAHGNSSII ADQIALKLVGPEGFVVTEAGFGADI GMEKFFNIKCRYSGLCPHVVVLVAT VRALKMHGGGPTVTAGLPLPKAYIQ ENLELVEKGFSNLKKQIENARMFGI PVVVAVNAFKTDTESELDLISRLSR EHGAFDAVKCTHWAEGGKGALALAQ AVQRAAQAPSSFQLLYDLKLPVEDK IRIIAQKIYGADDIELLPEAQHKAE VYTKQGFGNLPICMAKTHLSLSHNP EQKGVPTGFILPIRDIRASVGAGFL YPLVGTMSTMPGLPTRPCFYDIDLD PETEQVNGLFTRTRPLEQKLISEED LAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |