Recombinant Human Muscle RAS Oncogene Homolog, His-tagged

• Cat.No.: MRAS-1335H
• Product Overview: Recombinant human MRAS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: MRAS (Ras-related protein M-Ras) belongs to the RAS superfamily. These families are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors. MRAS serve as an important signal transducer for novel upstream stimuli in controlling cell proliferation.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 5 mM DTT, 40% glycerol, 200 mM NaCl, 2 mM EDTA.
• Molecular Weight: 25.7 kDa (225 aa), confirmed by MALDI-TOF
• Purity: > 90 % by SDS-PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKITREQ GKEMATKHNI PYIETSAKDP PLNVDKAFHD LVRVIRQQIP EKSQKKKKKT KWRGDRATGT HKLQC
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: HTLV-I infection; IL-3 Signaling Pathway; MAPK signaling pathway; Regulation of Actin Cytoskeleton; Tight junction

Gene Information

• Gene Name: MRAS muscle RAS oncogene homolog [ Homo sapiens ]
• Official Symbol: MRAS
• Synonyms: MRAS; muscle RAS oncogene homolog; M-RAs; RRAS3; R-RAS3; FLJ42964; ras-related protein M-Ras; OTTHUMP00000216882; OTTHUMP00000216883; OTTHUMP00000216886; OTTHUMP00000216887; muscle and microspikes RAS; ras-related protein R-Ras3
• Gene ID: 22808
• mRNA Refseq: NM_001085049
• Protein Refseq: NP_001078518
• MIM: 608435
• UniProt ID: O14807
• Chromosome Location: 3q22.3
• Function: GTP binding; GTP-dependent protein binding; GTPase activity; nucleotide binding