Recombinant Human MVD, His-tagged

• Cat.No.: MVD-26959TH
• Product Overview: Recombinant fragment, corresponding to amino acids 25-400 of Human MVD with an N terminal His tag; MWt 55kDa

Specification

• Description: The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.
• Form: Lyophilised:Reconstitute with 90 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: GKRDEELVLPINSSLSVTLHQDQLK TTTTAVISKDFTEDR IWLNGREEDVGQPRLQACLREIRCL ARKRRNSRDGDPL PSSLSCKVHVASVNNFPTAAGLASS AAGYACLAYTLAR VYGVESDLSEVARRGSGSACRSLYG GFVEWQMGEQADG KDSIARQVAPESHWPELRVLILVVS AEKKLTGSTVGMRASVETSPLLRFR AESVVPARMAEMARCIRERDFPSFA QLT MKDSNQFHATCLDTFPPISYLNAIS WRIIHLVHRFNAH HGDTKVAYTFDAGPNAVIFTLDDTV AEFVAAVWHGFPP GSNGDTFLKGLQVRPAPLSAELQAA LAMEPTPGGVKYI IVTQVGPGPQILDDPCAHLLGPDGL PKPAA
• Sequence Similarities: Belongs to the diphosphomevalonate decarboxylase family.

Gene Information

• Gene Name: MVD mevalonate (diphospho) decarboxylase [ Homo sapiens ]
• Official Symbol: MVD
• Synonyms: MVD; mevalonate (diphospho) decarboxylase; diphosphomevalonate decarboxylase; mevalonate pyrophosphate decarboxylase; MPD
• Gene ID: 4597
• mRNA Refseq: NM_002461
• Protein Refseq: NP_002452
• MIM: 603236
• Uniprot ID: P53602
• Chromosome Location: 16q24.3
• Pathway: C5 isoprenoid biosynthesis, mevalonate pathway, organism-specific biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, conserved biosystem; Cholesterol Biosynthesis, organism-specific biosystem; Cholesterol biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem
• Function: ATP binding; Hsp70 protein binding; diphosphomevalonate decarboxylase activity; diphosphomevalonate decarboxylase activity; kinase activity