Recombinant Human myostatin Propepetide

• Cat.No.: MSTN-120H
• Product Overview: Recombinant Human of the human Myostatin Propeptide produced inE.colia molecular mass of 27.8 kDa and containing 244 amino acid residues.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.
• Amino acid sequence: MNENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRR.
• Physical Appearance: Sterile Filtered white lyophilized (freeze-dried) powder.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: Lyophilized from 10 mM Acetic Acid.
• Applications: Western blotting, ELISA.
• Solubility: It is recommended to reconstitute the lyophilized Myostatin Propeptide in sterile 20 mM HCl at 0.1 mg/ml, which can then be further diluted to other aqueous solutions.
• Stability: Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20°C.

Gene Information

• Gene Name: MSTN myostatin [ Homo sapiens ]
• Synonyms: MSTN; myostatin; GDF8; growth differentiation factor 8; GDF-8; Myostatin
• Gene ID: 2660
• mRNA Refseq: NM_005259
• Protein Refseq: NP_005250
• MIM: 601788
• UniProt ID: O14793
• Chromosome Location: 2q32.2
• Function: cytokine activity; growth factor activity