Recombinant Human MYSM1 Protein (A2-M828), Tag Free
Cat.No. : | MYSM1-0683H |
Product Overview : | Recombinant Human GG-MYSM1(A2-M828 end) Protein was expressed in E. coli. |
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Description : | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome. |
Source : | E. coli |
Species : | Human |
Tag : | No tag |
Form : | Liquid |
Protein Length : | A2-M828 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | MYSM1 Myb-like, SWIRM and MPN domains 1 [ Homo sapiens (human) ] |
Official Symbol : | MYSM1 |
Synonyms : | MYSM1; Myb-like, SWIRM and MPN domains 1; histone H2A deubiquitinase MYSM1; KIAA1915; myb-like, SWIRM and MPN domain-containing protein 1; 2ADUB; 2A-DUB; RP4-592A1.1; DKFZp779J1554; DKFZp779J1721; |
Gene ID : | 114803 |
mRNA Refseq : | NM_001085487 |
Protein Refseq : | NP_001078956 |
MIM : | 612176 |
UniProt ID : | Q5VVJ2 |
Products Types
◆ Recombinant Protein | ||
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MYSM1-2497H | Recombinant Human MYSM1 Protein, MYC/DDK-tagged | +Inquiry |
MYSM1-0684H | Recombinant Human MYSM1 Protein (A2-M828), His tagged | +Inquiry |
Mysm1-4263M | Recombinant Mouse Mysm1 Protein, Myc/DDK-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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