| Description : |
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
91.8 kDa |
| AA Sequence : |
MSRRRHSDENDGGQPHKRRKTSDAN ETEDHLESLICKVGEKSACSLESNL EGLAGVLEADLPNYKSKILRLLCTV ARLLPEKLTIYTTLVGLLNARNYNF GGEFVEAMIRQLKESLKANNYNEAV YLVRFLSDLVNCHVIAAPSMVAMFE NFVSVTQEEDVPQVRRDWYVYAFLS SLPWVGKELYEKKDAEMDRIFANTE SYLKRRQKTHVPMLQVWTADKPHPQ EEYLDCLWAQIQKLKKDRWQERHIL RPYLAFDSILCEALQHNLPPFTPPP HTEDSVYPMPRVIFRMFDYTDDPEG PVMPGSHSVERFVIEENLHCIIKSH WKERKTCAAQLVSYPGKNKIPLNYH IVEVIFAELFQLPAPPHIDVMYTTL LIELCKLQPGSLPQVLAQATEMLYM RLDTMNTTCVDRFINWFSHHLSNFQ FRWSWEDWSDCLSQDPESPKPKFVR EVLEKCMRLSYHQRILDIVPPTFSA LCPANPTCIYKYGDESSNSLPGHSV ALCLAVAFKSKATNDEIFSILKDVP NPNQDDDDDEGFSFNPLKIEVFVQT LLHLAAKSFSHSFSALAKFHEVFKT LAESDEGKLHVLRVMFEVWRNHPQM IAVLVDKMIRTQIVDCAAVANWIFS SELSRDFTRLFVWEILHSTIRKMNK HVLKIQKELEEAKEKLARQHKRRSD DDDRSSDRKDGVLEEQIERLQEKVE SAQSEQKNLFLVIFQRFIMILTEHL VRCETDGTSVLTPWYKNCIERLQQI FLQHHQIIQQYMVTLENLLFTAELD PHILAVFQQFCALQATRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
