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Recombinant Human NECTIN3 Protein, C-His-tagged

Cat.No. : NECTIN3-239H
Product Overview : Recombinant Human NECTIN3 Protein with C-His tag was expressed in E. coli.
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Description : Nectin is a Ca2+-independent homophilic cell adhesion molecule that belongs to the immunoglobulin superfamily. Human Nectin is identical to the poliovirus receptor-related protein (PRR) and is identified to be the alphaherpesvirus entry mediator. Nectin constitutes a family consisting of at least Nectin 1, 2 and 3. Nectin 2 and 3 are ubiquitously expressed, whereas Nectin 1 is abundantly expressed in brain. Nectin 3, also designated as PRR3, has three splicing variants: Nectin 3α, 3β and 3γ. Nectin 3 is a transmembrane protein whose extracellular region contains three Ig-like domains. Nectin 3α and 3β, but not Nectin 3γ, have a C-terminal conserved motif (E/A-X-Y-V). This motif interacts with the PDZ domain of the F-Actin-binding protein, afadin, through which it is linked to the Actin cytoskeleton. Nectin 3α co-localizes with Nectin 2 at cadherin-based adheren junctions and interacts with afadin.
Source : E. coli
Species : Human
Tag : C-His
Molecular Mass : ~38 kDa
AA Sequence : GPIIVEPHVTAVWGKNVSLKCLIEV NETITQISWEKIHGKSSQTVAVHHP QYGFSVQGEYQGRVLFKNYSLNDAT ITLHNIGFSDSGKYICKAVTFPLGN AQSSTTVTVLVEPTVSLIKGPDSLI DGGNETVAAICIAATGKPVAHIDWE GDLGEMESTTTSFPNETATIISQYK LFPTRFARGRRITCVVKHPALEKDI RYSFILDIQYAPEVSVTGYDGNWFV GRKGVNLKCNADANPPPFKSVWSRL DGQWPDGLLASDNTLHFVHPLTFNY SGVYICKVTNSLGQRSDQKVIYISD PPTTTTLQPTIQWHPSTADIEDLAT EPKKLPFPLSTLATIKDDTIAT
Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
Notes : For research use only, not for use in diagnostic procedure.
Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
Concentration : ≥0.5 mg/mL
Storage Buffer : PBS, 4M Urea, pH7.4
Gene Name : NECTIN3 nectin cell adhesion molecule 3 [ Homo sapiens (human) ]
Official Symbol : NECTIN3
Synonyms : NECTIN3; nectin cell adhesion molecule 3; PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3; nectin-3; nectin 3; poliovirus receptor-related 3; poliovirus receptor-related protein 3
Gene ID : 25945
mRNA Refseq : NM_015480
Protein Refseq : NP_056295
MIM : 607147
UniProt ID : Q9NQS3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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