| Description : |
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
165.7 kDa |
| AA Sequence : |
MAGGAWGRLACYLEFLKKEELKEFQ LLLANKAHSRSSSGETPAQPEKTSG MEVASYLVAQYGEQRAWDLALHTWE QMGLRSLCAQAQEGAGHSPSFPYSP SEPHLGSPSQPTSTAVLMPWIHELP AGCTQGSERRVLRQLPDTSGRRWRE ISASLLYQALPSSPDHESPSQESPN APTSTAVLGSWGSPPQPSLAPREQE APGTQWPLDETSGIYYTEIRERERE KSEKGRPPWAAVVGTPPQAHTSLQP HHHPWEPSVRESLCSTWPWKNEDFN QKFTQLLLLQRPHPRSQDPLVKRSW PDYVEENRGHLIEIRDLFGPGLDTQ EPRIVILQGAAGIGKSTLARQVKEA WGRGQLYGDRFQHVFYFSCRELAQS KVVSLAELIGKDGTATPAPIRQILS RPERLLFILDGVDEPGWVLQEPSSE LCLHWSQPQPADALLGSLLGKTILP EASFLITARTTALQNLIPSLEQARW VEVLGFSESSRKEYFYRYFTDERQA IRAFRLVKSNKELWALCLVPWVSWL ACTCLMQQMKRKEKLTLTSKTTTTL CLHYLAQALQAQPLGPQLRDLCSLA AEGIWQKKTLFSPDDLRKHGLDGAI ISTFLKMGILQEHPIPLSYSFIHLC FQEFFAAMSYVLEDEKGRGKHSNCI IDLEKTLEAYGIHGLFGASTTRFLL GLLSDEGEREMENIFHCRLSQGRNL MQWVPSLQLLLQPHSLESLHCLYET RNKTFLTQVMAHFEEMGMCVETDME LLVCTFCIKFSRHVKKLQLIEGRQH RSTWSPTMVVLFRWVPVTDAYWQIL FSVLKVTRNLKELDLSGNSLSHSAV KSLCKTLRRPRCLLETLRLAGCGLT AEDCKDLAFGLRANQTLTELDLSFN VLTDAGAKHLCQRLRQPSCKLQRLQ LVSCGLTSDCCQDLASVLSASPSLK ELDLQQNNLDDVGVRLLCEGLRHPA CKLIRLGLDQTTLSDEMRQELRALE QEKPQLLIFSRRKPSVMTPTEGLDT GEMSNSTSSLKRQRLGSERAASHVA QANLKLLDVSKIFPIAEIAEESSPE VVPVELLCVPSPASQGDLHTKPLGT DDDFWGPTGPVATEVVDKEKNLYRV HFPVAGSYRWPNTGLCFVMREAVTV EIEFCVWDQFLGEINPQHSWMVAGP LLDIKAEPGAVEAVHLPHFVALQGG HVDTSLFQMAHFKEEGMLLEKPARV ELHHIVLENPSFSPLGVLLKMIHNA LRFIPVTSVVLLYHRVHPEEVTFHL YLIPSDCSIRKAIDDLEMKFQFVRI HKPPPLTPLYMGCRYTVSGSGSGML EILPKELELCYRSPGEDQLFSEFYV GHLGSGIRLQVKDKKDETLVWEALV KPGDLMPATTLIPPARIAVPSPLDA PQLLHFVDQYREQLIARVTSVEVVL DKLHGQVLSQEQYERVLAENTRPSQ MRKLFSLSQSWDRKCKDGLYQALKE THPHLIMELWEKGSKKGLLPLSSTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
