Recombinant Human NR1H3 Protein, His/SUMO-tagged

• Cat.No.: NR1H3-1377H
• Product Overview: Recombinant full length human NR1H3 protein was expressed in E. coli with N-terminal 6XHis-SUMO-tagged.

Specification

• Species: Human
• Source: E.coli
• Tag: His&SUMO
• Protein Length: Met46-Glu387
• Description: Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elents characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism .
• Form: Tris-based buffer，50% glycerol
• Molecular Mass: 61.7kDa
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.

Gene Information

• Gene Name: NR1H3 nuclear receptor subfamily 1, group H, member 3 [ Homo sapiens ]
• Official Symbol: NR1H3
• Synonyms: NR1H3; nuclear receptor subfamily 1, group H, member 3; LXRA; LXR-a; RLD-1; OTTHUMP00000198038; liver X receptor alpha; liver X receptor, alpha; liver X receptor-alpha; TLS/CHOP; Nuclear receptor subfamily 1 group H member 3; Nuclear orphan receptor LXR-alpha
• Gene ID: 10062
• mRNA Refseq: NM_001130101
• Protein Refseq: NP_001123573
• MIM: 602423
• UniProt ID: Q13133