Recombinant Human NRROS Protein (19-650 aa), His-Myc-tagged

• Cat.No.: NRROS-2547H
• Product Overview: Recombinant Human NRROS Protein (19-650 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Protein Description: Partial.

Specification

• Description: Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex. May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.
• Source: E. coli
• Species: Human
• Tag: His-Myc
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 74.5 kDa
• Protein length: 19-650 aa
• AA Sequence: WRNRSGTATAASQGVCKLVGGAADC RGQSLASVPSSLPPHARMLTLDANP LKTLWNHSLQPYPLLESLSLHSCHL ERISRGAFQEQGHLRSLVLGDNCLS ENYEETAAALHALPGLRRLDLSGNA LTEDMAALMLQNLSSLRSVSLAGNT IMRLDDSVFEGLERLRELDLQRNYI FEIEGGAFDGLAELRHLNLAFNNLP CIVDFGLTRLRVLNVSYNVLEWFLA TGGEAAFELETLDLSHNQLLFFPLL PQYSKLRTLLLRDNNMGFYRDLYNT SSPREMVAQFLLVDGNVTNITTVSL WEEFSSSDLADLRFLDMSQNQFQYL PDGFLRKMPSLSHLNLHQNCLMTLH IREHEPPGALTELDLSHNQLSELHL APGLASCLGSLRLFNLSSNQLLGVP PGLFANARNITTLDMSHNQISLCPL PAASDRVGPPSCVDFRNMASLRSLS LEGCGLGALPDCPFQGTSLTYLDLS SNWGVLNGSLAPLQDVAPMLQVLSL RNMGLHSSFMALDFSGFGNLRDLDL SGNCLTTFPRFGGSLALETLDLRRN SLTALPQKAVSEQLSRGLRTIYLSQ NPYDCCGVDGWGALQHGQTVADWAM VTCNLSSKIIRVTELPGGVPRDCKW ERLDLGL
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: NRROS negative regulator of reactive oxygen species [ Homo sapiens (human) ]
• Official Symbol: NRROS
• Synonyms: NRROS; GARPL1; LRRC33; UNQ3030; ELLP3030
• Gene ID: 375387
• mRNA Refseq: NM_198565
• Protein Refseq: NP_940967
• UniProt ID: Q86YC3