Recombinant Human NUDT15 Protein, His-tagged

• Cat.No.: NUDT15-11H
• Product Overview: Recombinant Human Nucleotide triphosphate diphosphatase NUDT15 with a C-terminal His-tag was produced in Nicotiana benthamiana by Agrobacterium-mediated transient expression.

Specification

• Description: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
• Source: Nicotiana benthamiana
• Species: Human
• Tag: His
• Form: Lyophilized
• Molecular Mass: 19.4 kDa
• Purity: >95%
• Storage: Lyophilized materials are stable for up to twelve months from date of receipt at -70 centigrade.
  It is recommended that reconstituted protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 20 mM HEPES pH8, 150 mM NaCl, 175 mM Trehalose Dihydrate.

Gene Information

• Gene Name: NUDT15 nudix hydrolase 15 [ Homo sapiens (human) ]
• Official Symbol: NUDT15
• Synonyms: NUDT15; nudix hydrolase 15; MTH2; NUDT15D; nucleotide triphosphate diphosphatase NUDT15; 8-oxo-dGTPase NUDT15; mutT homolog 2; nucleoside diphosphate-linked to another moiety X hydrolase 15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15; EC 3.6.1.9
• Gene ID: 55270
• mRNA Refseq: NM_018283
• Protein Refseq: NP_060753
• MIM: 615792
• UniProt ID: Q9NV35