| Description : |
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
93.6 kDa |
| AA Sequence : |
MDTEGFGELLQQAEQLAAETEGISE LPHVERNLQEIQQAGERLRSRTLTR TSQETADVKASVLLGSRGLDISHIS QRLESLSAATTFEPLEPVKDTDIQG FLKNEKDNALLSAIEESRKRTFGMA EEYHRESMLVEWEQVKQRILHTLLA SGEDALDFTQESEPSYISDVGPPGR SSLDNIEMAYARQIYIYNEKIVNGH LQPNLVDLCASVAELDDKSISDMWT MVKQMTDVLLTPATDALKNRSSVEV RMEFVRQALAYLEQSYKNYTLVTVF GNLHQAQLGGVPGTYQLVRSFLNIK LPAPLPGLQDGEVEGHPVWALIYYC MRCGDLLAASQVVNRAQHQLGEFKT WFQEYMNSKDRRLSPATENKLRLHY RRALRNNTDPYKRAVYCIIGRCDVT DNQSEVADKTEDYLWLKLNQVCFDD DGTSSPQDRLTLSQFQKQLLEDYGE SHFTVNQQPFLYFQVLFLTAQFEAA VAFLFRMERLRCHAVHVALVLFELK LLLKSSGQRAQLLSHEPGDPPCLRR LNFVRLLMLYTRKFESTDPREALQY FYFLRDEKDSQGENMFLRCVSELVI ESREFDMILGKLENDGSRKPGVIDK FTSDTKPIINKVASVAENKGLFEEA AKLYDLAKNADKVLELMNKLLSPVV PQISAPQSNKERLKNMALSIAERYR AQGISANKFVDSTFYLLLDLITFFD EYHSGHIDRAFDIIERLKLVPLNQE SVEERVAAFRNFSDEIRHNLSEVLL ATMNILFTQFKRLKGTSPSSSSRPQ RVIEDRDSQLRSQARTLITFAGMIP YRTSGDTNARLVQMEVLMNTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
