Recombinant Human OBFC2A Protein (1-204 aa), His-SUMO-tagged

• Cat.No.: OBFC2A-1094H
• Product Overview: Recombinant Human OBFC2A Protein (1-204 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Full Length.

Specification

• Description: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 38.4 kDa
• Protein length: 1-204 aa
• AA Sequence: MNRVNDPLIFIRDIKPGLKNLNVVF IVLEIGRVTKTKDGHEVRSCKVADK TGSITISVWDEIGGLIQPGDIIRLT RGYASMWKGCLTLYTGRGGELQKIG EFCMVYSEVPNFSEPNPDYRGQQNK GAQSEQKNNSMNSNMGTGTFGPVGN GVHTGPESREHQFSHAGRSNGRGLI NPQLQGTASNQTVMTTISNGRDPRR AFKR
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: NABP1 nucleic acid binding protein 1 [ Homo sapiens (human) ]
• Official Symbol: OBFC2A
• Synonyms: NABP1; SSB2; OBFC2A; SOSS-B2
• Gene ID: 64859
• mRNA Refseq: NM_001031716
• Protein Refseq: NP_001026886
• MIM: 612103
• UniProt ID: Q96AH0